Metformin and longevity (METAL): a window of opportunity study investigating the biological effects of metformin in localised prostate cancer

Answers

Answer 1

Metformin and longevity (METAL): a window of opportunity study investigating the biological effects of metformin in localized prostate cancer is totally based on the working of metformin .

What is Metformin? A biguanide oral hypoglycaemic drug called metformin is frequently prescribed to treat type 2 diabetes mellitus. Metformin has been linked to a decreased risk of cancer incidence of a number of solid tumors, including prostate cancer, in addition to its anti-diabetic impact (PCa).The biochemical mechanisms behind these observations in PCa have not yet been thoroughly characterized. The formation and progression of PCa are thought to be influenced by high insulin and insulin-like growth factor-1 (IGF-1) levels, hence one theory is that the indirect insulin reducing impact may have an anti-neoplastic effect.

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Related Questions

mportant vocabulary continued:what is the difference between a unicellular organism and a multicellular organism?

Answers

Answer:

Unicellular organisms are made up of only one cell that carries out all of the functions needed by the organism, while multicellular organisms use many different cells to function. ... Multicellular organisms are composed of more than one cell, with groups of cells differentiating to take on specialized functions.

Explanation:

please thank to all my answer and please mark as brilliant

Unicellular organisms are made up of only one cell that carries out all of the functions needed by the organism, while multicellular organisms use many different cells to function. ... Multicellular organisms are composed of more than one cell, with groups of cells differentiating to take on specialized functions.

which ecosystem has the greatest biological diversity and therefore the highest sustainability

Answers

Answer:

Tropical rain forests on land and coral reefs in marine systems are among the most biologically diverse ecosystems on Earth and have become the focus of popular attention.

Explanation:

definitely D because a rainforest is extremely vast when it comes to different species

Answer:

Species richness is greatest in tropical ecosystems. Tropical rain forests on land and coral reefs in marine systems are among the most biologically diverse ecosystems on Earth and have become the focus of popular attention.

Suggest a way that each farm could change their farming practices to prevent pollution of the river with nitrates. Gizmo

Answers

Answer:

An improved agricultural practices such as adjustment of application rate, application of the right amount of nitrogen, use of slow controlled release fertiliser, applying nitrogen fertilisers when least susceptible to loss, crop rotation

Explanation:

The various ways are available to reduce or prevent pollution of the river with nitrates, the most effective is:- reducing or not use of artificial or industrial-based nitrogen fertilizers and using biofertilizers.

Agriculture or farming contributes to water pollution when using fertilizers more than the required amount or easily lost fertilizers. This increases the of nutrients including nitrates in the river that cause the growth of algal bloom and eutrophication.

There are several ways to control the nitrates in the river:

adjustment of using rateapplication of the right amount of nitrogenslow-release fertilizernitrogen fertilizers when least susceptible to losscrop-rotation and use of legumesavoiding over-irrigation

Thus, the correct answer is: reducing or not using artificial or industrial-based nitrogen fertilizers and using biofertilizers.

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Only a few natural elements have a greater density than gold. They are: ??


15 POINTS AND BRAINLIEST FOR CORRECT ANSWERS!!!

Answers

Plutonium

Neptunium

osmium

let me know if it's correct or not, these were the only ones I could think of.

Few natural elements have a greater density than gold are plutonium, neptunium, and osmium.

What is an element?

An element is define as a type of substance that is impossible to  break into smaller pieces by the help of chemical process. There are several rules that should be followed at the time of assinging name of the elements. The first rule is name of the element is not a proper noun. The second rule is the symbols of the element that must be of one or more than one symbol.

Density is define as the mass per unit volume it means that 1 kg mass present in 1 meter cube is called density, density is also states that the how compact an material.

Mathematically

Density = mass/volume

S.I unit of density is kg/m^3

Density is higher in solid as compare to liquid and density of liquid is higher than gas so density is in order of SOLID>LIQUID>GAS. So we know that solid is compact in nature as compare to liquid and gas.

Therefore, Few natural elements have a greater density than gold are plutonium, neptunium, and osmium.

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Construct an argumentative paragraph. Do you believe it's ethical or unethical to artificially select traits in plants and or animals? Provide evidenco to suoport your claims. It doesn't matter what side you chose, but I need it asap.​I will give you any mark you want.​

Answers

Answer:

The ethics of artificially inserting traits in animals has been in the practice for years in the form of selective breeding, but should scientists really be editing DNA to the extent they are today? I don't believe they should. Life itself should construct itself without us interfering. Making a brand new plant just because it looks nice doesn't account for many factors, including the fact that it could be harmful to nearby plants if pollinated. In addition, generic engineering costs quite a lot of money, which should be used on other more cost effective methods, such as improving agriculture rather than creating a whole new plant that could harm entire crops. Genetic engineering isn't a necessity and humans should not play God with plant and animal life.

What is the purpose of crossing-over in meiosis?
A.to create mutations in gametes to increase variation
B.to randomly separate homologous chromosome pairs
C.to reduce the number of chromosomes in gametes by one half
D.to create new combinations of DNA on homologous chromosomes

Answers

Answer:

A

Explanation:

During prophase I of meiosis, crossing over that occurs between non-sister chromatids of homologous chromosomes pairs occurs at chiasma results in the exchange of genetic material. This produces new genetic combinations in gametes leading to variation.

“A” is the correct answer!!!!!!!

Explain the statement “all cells perform respiration but not all perform photosynthesis”.

Answers

Photosynthesis converts carbon dioxide and water into oxygen and glucose. This occurs in plants. Glucose is used as food by plants and has oxygen as a by-product. Cellular respiration converts oxygen and glucose into water and carbon dioxide. Water and carbon dioxide are by- products and ATP is energy that is transformed from the process.

All cells perform respiration but not all perform photosynthesis because of the absence of the plastids.

Respiration:

It is a process by which organisms produce energy by degrading glucose.

It is occur in mitochondria in eukaryotes and in plasma membrane in prokaryotes.

Photosynthesis-

It is a process by which photoautotrophic organisms produce glucose from the Carbon dioxide and water by capturing the sunlight using chlorophyll.

Chlorophyll is found in the plastid of plants and algae.

Therefore, all cells perform respiration but not all perform photosynthesis because of the absence of the plastids.

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The eyespot of a euglena is damaged. How will this affect the organism's basic functions?
A The euglena will lose its flexibility
B. The euglena will be unable to reproduce.
C. The rate of photosynthesis in the euglena will be reduced.
D. The ability of the euglena to move away from light will be reduced.

Answers

C, just stole the answer from some one else asking it.

hope someone can help me​

Answers

i think it's the independent variable

Answer:

I think it would be A or E? possibly, im not so sure ;v;

When we talk about soil depletion, which soil horizon are we talking about? Thank you

Answers

Answer:

Surface Horizon (A)

Nutrient depletion of soils is a widespread soil degradation phenomenon that occurs as a consequence of soil erosion (it is the topsoil in which generally most soil nutrients are present that erodes fastest) but also because of poor management practices, such as slash and burn and other subsistence agricultural.

What are some factors that can cause observed evolutionary change?

Answers

Answer:

There are four such forces: mutation, gene flow, genetic drift, and natural selection.

Explanation:

Answer:

natural selection, random genetic drift, mutation, population mating structure, and culture.

Explanation:

I hope this helps! ^^

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the epicenter of an earthquake is:

A. along a fault
B. the same as the focus
C. directly above the focus
D. directly below the focus

Answers

Answer:

I'm positive its C :)

Explanation:

Have a great day

35 POINTS !!!! Part A
An organism’s adaptations are specific to its native environment. An organism that lives in a coniferous forest will have different adaptations compared to an animal that lives in a tropical rain forest. The following graphs show the temperature and precipitation throughout the year for two different forests: a coniferous forest in Canada, and a tropical rain forest in Belize.

Evaluate the graphs, and then explain why plants from these two ecosystems will have different adaptations. In your answer, explain the survival challenges that plants face in these two environments.

Coniferous Forest

graphical representations of the temperature and precipitation in a coniferous forest from January to December

Tropical Rain Forest

a graphical representation of the temperature (top image) and precipitation (bottom image) in a tropical rain forest from January to December

Answers

Answer:

Ok so one graph shows the temperature it’s in the negative so the plant can’t survive all you have to say is the plant is struggling in the coniferous forest because of the climate there is not enough sun and not enough water the graph next to it shows the amount of water it’s getting and horizontally it’s showing the months and the plants progress the plant is barley surviving and will most likely die vs in the tropical rainforest as you can see the temperature is sunny all throughout the year it’s getting the warmth it needs and the graph next to it is again showing the amount of water it is receiving at first there’s not a lot but pushing more into spring and summer time going farther into colder whether there a lot more rain and because it’s a tropical forest the rain doesn’t turn into snow due with the warm climate it’s the perfect weather for the plant and it easily adapts to this weather because that is the natural environment plants need to grow no matter the plant they all need sun and water I hope that helped this is supposed to be a written out answer you can put it in your own words if you like or use it that way but I just did it and I got a 90% on the grade


The sugars of a DNA and RNA molecule are alternated with in the backbone of the strand

Answers

Answer:

A phosphate backbone is the portion of the DNA double helix that provides structural support to the molecule. DNA consists of two strands that wind around each other like a twisted ladder. Each strand has a backbone made of alternating sugar (deoxyribose) and phosphate groups. Attached to each sugar is one of four bases--adenine (A), cytosine (C), guanine (G), or thymine (T). The two strands are held together by bonds between the bases, with adenine forming a base pair with thymine, and cytosine forming a base pair with guanine.

What epigenetic marker changes cause chromatin to open up?

Answers

Answer Several lifestyle factors have been identified that might modify epigenetic patterns, such as diet, obesity, physical activity, tobacco smoking, alcohol consumption, environmental pollutants, psychological stress, and working on night shifts.:changes to the histone tails act indirectly on the DNA. For example, lysine acetylation may create a binding site for chromatin-modifying enzymes (or transcription machinery as well). This chromatin remodeler can then cause changes to the state of the chromatin. hope this helps ❤️❤️❤️

Explanation:

The changes with respect to the epigenetic marker should result to the chromatin at the time of opening up because When transcription factors could access the DNA binding sites.

Reasons of chromatin:

It is the material that comprises of the chromosome that involved the DNA and protein. The major protein is called as the histones. It should be acted as the packaging elements with respect to the DNA.  

Therefore, The changes with respect to the epigenetic marker should result to the chromatin at the time of opening up because When transcription factors could access the DNA binding sites and the gene expression is not be blocked.

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The childhood viral disease associated with skin blisters and mild fever is _____.

polio
rubella
mumps
chicken pox

Answers

I believe it should be chicken pox

the pencil and the book both fall down at the same time because

Answers

Answer:

They both weighed tha same

Explanation:

A book is heavier than a pencil, but if they are equal in weight. Then they will fall at the same time

Hope this helped

Gravity works independently of mass :) hope this helps and have a nice day!

Which feature of chytrids makes them different from the other types of fungi? the material that strengthens their cell walls the special digestive material they release their use of budding to reproduce their ability to live in dry environments

Answers

Answer:

the material that strengthens their cell walls

Explanation:

Chytrids originate from the kingdom fungi and a division known as Chytridiomycota. They contain a feature of unique characteristics by the presence of the chitin and the cellulose cell wall. The chitin made up the component of their cell wall in fungi but in Chytrids, the cellulose helps to strengthens their cell walls.

Answer:

A. the material that strengthens their cell walls

1. Submit your observations of the chicken leg dissection.



2. Were you able to determine how the chicken moves?



3. What characteristics of muscles help you determine the direction of the movement?

Answers

Answer:

1. Submit your observations of the chicken leg dissection.

The first thing that I saw was the skin. This one has bumps on it. Underneath, when I carefully cut it, I could see a yellow layer which is fat. Under the fat, there is a thick pink tissue, the muscles. The muscle is in contact with the bones and attached to them by the tendons. They look thin and white and are at the muscles' ends since they attach them to the bones.

2. Were you able to determine how the chicken moves?

Yes, muscles work in pairs, so when I pull from a specific tendon, the leg bends since the muscle contracts to do this movement. Then this muscle will relax, another muscle will contract itself, and a tendon will pull the bone to return the leg to a straight position.

When one of these muscles contracts, the other relaxes to allow the bone's movement in a specific direction. Then this muscle relaxes and allows the leg's movement in the opposite direction since the muscle that was lax before now is contracting itself to extend the leg. There are a flexor and an extensor muscle.

3. What characteristics of muscles help you determine the direction of the movement?

The characteristics that help me determine the movement's direction were:

The position that the muscles have concerning the joints and the bones. The tendons at the end of the muscles and bones.

By following the muscle, the tendon, and where it is in the joint, I could determine the movement's direction.

Explanation:

When we observe a chicken leg dissection, we can determine the components that it has and how all the elements work together to move the leg. Even though the mechanism and structure are not the same as in a human body, we can see how muscles, bones, tendons, and joints work not only in animals but also in humans to allow movement.

Most leopards are golden in color with large, circular black spots to provide camouflage. There is one gene that controls the amount of pigments produced by a cell in order to create that color. A mutation on that gene can have any of the following effects. Which is the most likely result of a mutation if the leopard lives in a dense forest?
a white leopard, with albinism
a normal colored leopard
a black leopard, with melanism
no leopard, it would not survive the mutation

Answers

A black leopard, because it can better blend in with its surroundings

The Sun appears to move across the sky each day. What causes this?

Answers

Answer:

The earth is turning.

Explanation:

when the earth turns it causes the sun to move from one part of the sky to the other. The earth revolves around the sun. So when it become night time for example, the sun is just on the other side of the earth.

How would Earth be different without the greenhouse effect?(1 point)

A.There would be more solar energy reaching Earth.
B.The atmosphere would contain more methane.
C.The oceans would contain more carbonic acid.
D.There would be more ice on Earth's surface.

Answers

Answer:

I think the answer will be:

D. There would be more ice on Earth's surface.

Explanation:

Without the greenhouse effect, the Earth would have an average temperature of -18°c and life would not be able to survive.

The Earth would be different if the greenhouse gasses didn't even exist.

The Earth's surface would be covered in more ice.

So, option D. is correct.

Define greenhouse effect.

The greenhouse effect happens when solar energy passes through a planetary system and heats its surface, but the air prevents the energy from going directly to space, leading in a warming climate.

The Earth would be different if the greenhouse gasses didn't even exist.

The Earth's surface would be covered in more ice. So, option D. is correct.

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A large group of seals from Prince Harold Coast Antarctica has emigrated to Oates Coast Antarctica How will this impact the remaining seal population Prince Hard Coast
A The Prince Harold population will decrease
B. The Prince Harold population will increase
C The Prince Harold population will be reduced to zero
DThis will have no impact on the Prince Harold population

Answers

Answer:

B

Explanation:

Because now it’s a larger group

B because it will increase

how do organisms with many cell types develop from a single cell

Answers

Answer:

Organisms develop from a single cell into many cell types, which are organized into tissues and organs. During development, cells use both inherited info and external signals from neighbors to “decide on” their behavior and identity.

Cell division, torso axis formation, tissue and organ development are all part of development, and cell differentiation refers to acquiring a final cell type identity.

What is cell division?

The process by which a parent cell divides into two daughter cells is known as cell division.

Cell division is usually part of a larger cell cycle during which the cell grows and replicates its chromosomes before dividing.

Cell division occurs in two stages: mitosis and meiosis. When most people say "cell division," they're referring to mitosis, the process of creating new body cells.

Meiosis is the process by which egg and sperm cells are formed. Mitosis is a necessary process for life.

Multicellular organisms form in a variety of ways, including cell division and the aggregation of many single cells. Colonial organisms form when many identical individuals band together to form a colony.

Thus, this way, organisms with many cell types develop from a single cell.

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Which statement describes the formation of stars?
I'm pretty sure its heat and gasses

Answers

Answer:

c

Explanation:

Stars start out as gas dust and other particles hope this helped and hope its correct have a great day!!

Answer:

The correct answer is 'Dust and Gases Contract'

Explanation:

When Dust and Gases shrink, or become smaller, a star is formed.

Describe how new hair fibers are formed

Answers

Answer:

Taking nutrients from the dermal papilla, the hair bulb generates new hair cells. As these cells move up through the hair root, they mature through a process called keratinization, fill with fibrous protein and lose their nucleus.

Explanation:

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A stop enzyme is used in protein synthesis to stop tRNA from carrying messages from the DNA to the ribosome.
True
False

Answers


A stop enzyme is used in protein synthesis to stop tRNA from carrying messages from the DNA to the ribosome.
True
False

pls help and only answer if you can please

Answers

Answer:

A

Explanation:

I got this by process of elimination because I know all those other answers are wrong

Answer:

I think the answer is A.

what's mitosis and meiosis?​

Answers

Answer:

MITOSIS AND MEIOSIS*

Most of the time when people refer to “cell division,” they mean mitosis, the process of making new body cells. Meiosis is the type of cell division that creates egg and sperm cells. ... During mitosis, a cell duplicates all of its contents, including its chromosomes, and splits to form two identical daughter cells.

What meiosis means?

Meiosis is a type of cell division that reduces the number of chromosomes in the parent cell by half and produces four gamete cells. This process is required to produce egg and sperm cells for sexual reproduction. ... Meiosis begins with a parent cell that is diploid, meaning it has two copies of each chromosome.

What is mitosis explain?

Mitosis is a process where a single cell divides into two identical daughter cells (cell division). During mitosis one cell? divides once to form two identical cells. The major purpose of mitosis is for growth and to replace worn out cells.

What is meiosis important?

Meiosis is important because it ensures that all organisms produced via sexual reproduction contain the correct number of chromosomes. Meiosis also produces genetic variation by way of the process of recombination.

What is Mitosis important?

Mitosis is a way of making more cells that are genetically the same as the parent cell. It plays an important part in the development of embryos, and it is important for the growth and development of our bodies as well. Mitosis produces new cells, and replaces cells that are old, lost or damaged.

What is Mitosis means?

Mitosis is a process where a single cell divides into two identical daughter cells (cell division). ... The major purpose of mitosis is for growth and to replace worn out cells.

What Meiosis explain?

Meiosis is a type of cell division that reduces the number of chromosomes in the parent cell by half and produces four gamete cells. This process is required to produce egg and sperm cells for sexual reproduction. ... Meiosis begins following one round of DNA replication in cells in the male or female sex organs.

Explanation:

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A teacher uses the diagram below to help him explain hereditary to a group of students. which of these combinations identifies the appropriate labels in the order as shown in the diagram (1, 2, 3)
a.)chromosome, DNA, gene
b.)chromosome, gene, DNA
c.) DNA, chromosome, gene
d.) DNA, gene, chromosome

Answers

The answer is b hehehe

Answer:

The answer is b

Explanation:

Other Questions
Like bias and confounding, effect modification is a natural phenomenon of scientific interest that the investigator needs to eliminate.a. Trueb. False Consider the following data field and method.private ArrayList list;public void mystery(int n) {for (int k = 0; k < n; k++) {Object obj = list.remove(0);list.add(obj);}}Assume that list has been initialized with the following Integer objects.[12, 9, 7, 8, 4, 3, 6, 11, 1]Which of the following represents the list as a result of a call to mystery(3)?a. [12, 9, 8, 4, 3, 6, 11, 1, 7]b. [12, 9, 7, 8, 4, 6, 11, 1, 3]c. [12, 9, 7, 4, 3, 6, 11, 1, 8]d. [8, 4, 3, 6, 11, 1, 12, 9, 7]e. [1, 11, 6, 12, 9, 7, 8, 4, 3] The Nut Shack sells cashews for $6.80 per pound and Brazil nuts for $4.70 per pound. How much ofeach type should be used to make a 37 pound mixture that sells for $5.78 per pound?Round answers to the nearest pound.pounds of cashewspounds of Brazil nuts> Next Question In this exercise you will draw the Lewis structure for the five molecules/ions indicated below. For the Lewis structures, please include formal charges for each atom and any important resonance structures. State the electronic and molecular geometries. For each structure you should also sketch the molecular geometry (shape), indicate whether the molecule is polar or non-polar, and draw a net molecular dipole (if it exists). Your work should be presented neatly in the space below or at the back of the page. Work that is not clearly presented and legible will not be graded. Six points for each molecule/ion for a total of 30 points for the assignment. Assignment Checklist - for each molecule/ion you should have/do: 1. Lewis structure (show the valence electron count, formal charges, and important resonance structures) 2. State electronic (EG) and molecular geometries (MG) 3. Sketch molecular geometry 4. State whether the molecule is polar or non-polar, and draw a net dipole (if applicable) Molecules and ions SiO32- PO33- SbF2- IF 2 NO2 Which one of the following is the risk that market rates may increase causing the price of a bond to decline? A. yield risk B. interest rate risk C. reinvestment risk D. inflation risk Choose from the following list of terms and phrases to best complete the following statements 1. The category includes short-term highly liquid investment assets that are readily convertible to a known cash amount and sufficiently close to their due dates so that their market value will not greatly change refers to a company's ability to pay for its current liabilities 2. The term 3. Examples of include currency and coins Cash Cash Budget Cash Equivalents Liquidity The largest entry in a node ns right subtree is:________ The Citric Acid Cycle is regulated in a manner similar to Glycolysis. Which molecule is an allosteric activator of both of those pathways? A. ATP B NAD+ C. ADP D. Citrate E. NADH A truck's 42-in.-diameter wheels are turning at 505 rpm. Find the linear speed of the truck in mph: miles/hour Write answer as an exact expression using pi for a. No need to simplify Assume there is NO friction between the bracket A and the ground or at the pulleys, but there IS friction between bracket A and mass B. Assume mass C is quite small. Pick the two correct statements. No matter how small the mass of C, the bracket will move. Only if the mass of C is large enough, the bracket A will move. The total force on the bracket is 2T to the right, where Tis the tension in the cable. Direction of friction on mass B is to the right. A significant difference between the direct material purchases budget and the production budget is that the production budget considersa. finished goods inventory levels, while the material purchases budget considers raw material inventory levelsb. beginning and ending finished goods inventory amounts, which are not part of a direct material purchases budget.c. units to be produced, while the direct material purchases budget is based on units to be sold.d. the capacity of the factory, while the direct material purchases budget does not. A 0. 2 kg cart is released from rest at the top of a frictionless ramp with a height of 1. 4 meters. State the initial type of energy in the cart-Earth system when the cart is released at the top of the ramp a. by how much does the volume reading increase when the brass block is placed in the cylinder? (assume that no water leaves the cylinder.) explain. Microwaves of wavelength 3. 00 cm are incident normally on arow of parallel metal rods. The separation of the rods is 8. 00 cm. The first order diffraction maximum is observed at an angle of 22. 0to the direction of the incident waves. What is the angle between the first and second order diffractionmaxima? all medical gas and vacuum systems shall be protected against all of the following exceptA) combustible liquids. B) corrosion. C) freezing. D) physical damage 3. Triangle ABC is an equilateral triangle (all angles are equal and all side lengths are equal) and triangle CDE is a right triangle. If the length of side AE is 20 units, what is the length of side BD. A - 12 unitsB - 14 unitsC - 16 unitsD - 18 unitsE - 20 units A committee of nurse have been tasked with reviewing an increase in central line infections. explaint he process that they should follow Part 4: Arguing from EvidenceIndividually, write a complete CER paragraph below.The first sentence should be a statement that answers the Guiding Question: Which specific dyemolecule(s) gives each Skittle its color?Next, use observations from the bands on your gel as evidence to support your claim. Finally, explain why the evidence supports the claim (what scientific principles explain what you see ingel?) if x=15cm , does the laser beam refract back into the air through side b or reflect from side b back into the water? Material through which water readily flows is termed . A. Fluent B. Porous C. Permeable. C. Permeable.